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Erectile Dysfunction (ED), called impotence, is a medical condition characterized by the constant or recurrent inability to attain or maintain an erection enough for satisfactory sexual performance. In simpler terms, it is when a man faces difficulty getting and keeping an erection firm enough for sexual intercourse.

Factors that cause ER

1. Physical Factors

Cardiovascular issues:

Conditions such as high blood pressure, atherosclerosis (hardening of the arteries), and diabetes can stop blood flow to the penis, making it tough to achieve and maintain an erection.

Neurological disorders:

Conditions like multiple sclerosis, Parkinson’s disease, and spinal cord injuries can interact with the nerve signals needed for erections.

Hormonal imbalances:

Low testosterone levels can lead to ED.

1. Psychological Factors:

Stress and anxiety:

Psychological depressors, such as work-related stress or relationship issues, can also cause temporary episodes of ED.

Depression:

Mental health conditions like depression can affect sexual function.

Performance anxiety:

Fear of performing sexually perfect can create a self-fulfilling prophecy and lead to ED.

How does Cialis work?

Here is how Cialis works in the context of treating ED

Phosphodiesterase Type 5 (PDE5) Inhibition:

Cialis relates to a class of drugs known as phosphodiesterase type 5 (PDE5) inhibitors. PDE5 is an enzyme available in the smooth muscle cells of the penis and blood vessel walls throughout the body. It plays a role in regulating blood flow. When a man becomes sexually active, nitric oxide releases in the erectile tissue of the penis. Nitric oxide then activates an enzyme called guanylate cyclase, which causes an increase in cyclic guanosine monophosphate (cGMP) levels.

Enhancing Nitric Oxide-CGMP Pathway:

Cialis works by inhibiting the PDE5 enzyme. It inhibits the breakdown of cGMP, enabling it to accumulate and retain in the penis. Elevated cGMP levels relax and dilate the smooth muscle in the blood vessels of the penis. This relaxation of the smooth muscle allows an increased blood flow into the penile arteries, which leads to the overabundance of the erectile tissue and the formation of a firm and lasting erection.

Timing and Effectiveness:

It is important to note that Cialis does not instantly cause an erection. Sexual arousal and stimulation are still necessary for the medication to work. However, the effects of Cialis can last significantly longer besides other ED medications, with some individuals experiencing its effects for up to 36 hours. This extended duration of effectiveness has earned Cialis the nickname “the weekend pill.

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